Professor Reynolds was appointed Head of the School of Dental Science at the University of Melbourne in 1998 and Foundation Head of the Melbourne Dental School at the University of Melbourne in 2010.  He is also Associate Dean of the Faculty of Medicine, Dentistry and Health Sciences of the University of Melbourne and Chief Executive Officer of the Cooperative Research Centre for Oral Health.  He has been researching and teaching for over 20 years on the aetiology and prevention of oral diseases.  He has over 200 scientific publications and 19 patents.

Professor EC Reynolds has over 20 years experience in molecular biology, biochemistry, immunology, microbiology, cariology and periodontology. He has published over 172 peer-reviewed publications and 19 patents and has supervised over 50 BSc(Hons), BDentStud, MDSc and PhD students. Seven patents have been licensed to Recaldent Pty Ltd and GC (Japan) and another six have been licensed to CSL Ltd. Professor Reynolds has been closely involved in technology transfer associated with all licence agreements.

In 1999 Professor Reynolds was invited to join the Editorial Board of the Journal of Dental Research; the pre-eminent dental journal of the International Association for Dental Research (IADR) and the American Association for Dental Research (AADR).